1026632-68-7Relevant articles and documents
Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones
Sui, Zhihua,Nguyen, Van N.,Altom, Jason,Fernandez, Jeffrey,Hilliard, Jamese J.,Bernstein, Jeffrey I.,Barrett, John F.,Ohemeng, Kwasi A
, p. 381 - 387 (2007/10/03)
A series of aza-flavones (3-hydroxy-2-phenyl-4-quinolones) were designed and synthesized as inhibitors of bacterial DNA-gyrase and mammalian topoisomerase II. Structure activity relationships of the compounds against each of the enzymes are discussed.