1026641-73-5Relevant academic research and scientific papers
Enantiospecific synthesis of a protected equivalent of APTO, the β-amino acid fragment of microsclerodermins C and D, by aziridino-γ-lactone methodology
Tarrade-Matha, Aurelie,Valle, Marcelo Siqueira,Tercinier, Pierre,Dauban, Philippe,Dodd, Robert H.
experimental part, p. 673 - 686 (2009/07/17)
The efficient synthesis of a protected form of (2S,3R,4S,5S,7E)-3-amino-8- phenyl-2,4,5-trihydroxyoct-7-enoic acid (APTO), the α-hydroxy β-amino acid component of microsclerodermins C and D, 23-membered cyclic peptides isolated from lithistid sponges, is
Enantiospecific Total Synthesis of (-)-Polyoxamic Acid Using 2,3-Aziridino-γ-lactone Methodology
Tarrade, Aurelie,Dauban, Philippe,Dodd, Robert H.
, p. 9521 - 9524 (2007/10/03)
The non-natural enantiomer of polyoxamic acid was synthesized in six steps from 2,3-aziridino-γ-lactone 7 with an overall yield of 10%. The key step of the strategy is a deprotection-protection sequence on the nitrogen atom of the aziridine ring required
