1026660-76-3

Basic information

• Product Name: di-tert-butyl 5-[2-hydroxy-3-(4-octylphenoxy)propoxy]indole-1,2-carboxylate
• Synonyms: di-tert-butyl 5-[2-hydroxy-3-(4-octylphenoxy)propoxy]indole-1,2-carboxylate
• CAS NO: 1026660-76-3
• Molecular Weight: 595.777
• Mol File: 1026660-76-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: di-tert-butyl 5-[2-hydroxy-3-(4-octylphenoxy)propoxy]indole-1,2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: di-tert-butyl 5-[2-hydroxy-3-(4-octylphenoxy)propoxy]indole-1,2-carboxylate(1026660-76-3)
• EPA Substance Registry System: di-tert-butyl 5-[2-hydroxy-3-(4-octylphenoxy)propoxy]indole-1,2-carboxylate(1026660-76-3)

Safety Data

• Hazardous Substances Data: 1026660-76-3(Hazardous Substances Data)

Upstream product

• 1026660-75-2 di-tert-butyl 5-(oxiran-2-ylmethoxy)indole-1,2-carboxylate 
• 1806-26-4 p-Octylphenol 

Downstream Products

• 1026660-77-4 di-tert-butyl 5-[3-(4-octylphenoxy)-2-oxopropoxy]indole-1,2-carboxylate 

Relevant articles and documents

1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Synthesis, biological activity, metabolic stability, and solubility

Indole-5-carboxylic acids with 3-aryloxy-2-oxopropyl residues in position 1 were previously reported to be potent inhibitors of cytosolic phospholipase A2α (cPLA2α) isolated from human platelets. In continuation of our attempts to develop novel cPLA2α inhibitors, a series of structurally related indole-2-carboxylic acids containing 3-aryloxy-2-oxopropoxy residues in position 5 were synthesized and tested for their cPLA2α-inhibitory potency. Furthermore, the thermodynamic solubility of these compounds and their metabolic stability against rat liver microsomes were evaluated.