1026665-91-7Relevant academic research and scientific papers
Rational design of a novel peripherally-restricted, orally active CB 1 cannabinoid antagonist containing a 2,3-diarylpyrrole motif
Hortala, Laurent,Rinaldi-Carmona, Murielle,Congy, Christian,Boulu, Laurent,Sadoun, Freddy,Fabre, Gerard,Finance, Olivier,Barth, Francis
scheme or table, p. 4573 - 4577 (2010/10/02)
A new series of 2,3-diarylpyrroles have been prepared and evaluated as CB1 antagonists. Modulation of the topological polar surface area allowed the identification of high affinity peripherally-restricted CB 1 antagonists. Compound 1
PYRROLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
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Page/Page column 13, (2009/12/04)
The invention relates to compounds having the formula (I): Wherein R1, R2, R3, R4, R5, R6, R7 and R9 and A-R9 are as defined herein. Also disclosed are the
