1026732-85-3

Basic information

• Product Name: 1-(3-Cyano-phenyl)-3-(2-{2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetyl}-phenyl)-urea
• Synonyms: 1-(3-Cyano-phenyl)-3-(2-{2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetyl}-phenyl)-urea
• CAS NO: 1026732-85-3
• Molecular Weight: 470.546
• Mol File: 1026732-85-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-Cyano-phenyl)-3-(2-{2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetyl}-phenyl)-urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Cyano-phenyl)-3-(2-{2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetyl}-phenyl)-urea(1026732-85-3)
• EPA Substance Registry System: 1-(3-Cyano-phenyl)-3-(2-{2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetyl}-phenyl)-urea(1026732-85-3)

Safety Data

• Hazardous Substances Data: 1026732-85-3(Hazardous Substances Data)

Upstream product

• 16413-26-6 3-cyanophenyl isocyanate 
• 1026343-19-0 1-(2-amino-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone 
• 6851-99-6 2-bromo-1-(2-nitrophenyl)ethanone 
• 92822-02-1 4-(4-fluorobenzyl)piperidine 

Relevant articles and documents

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists

Structure-activity relationship (SAR) studies of initial screening hits from our corporate library of compounds and a structurally related series of CCR1 receptor antagonists were used to determine that an N-(alkyl)benzylpiperidine is an essential pharmacophore for selective CCR3 antagonists. Further SAR studies that introduced N-(ureidoalkyl) substituents improved the binding potency of these compounds from the micromolar to the low nanomolar range. This new series of compounds also displays highly potent, in vitro functional CCR3-mediated antagonism of eotaxin-induced Ca2+ mobilization and chemotaxis of human eosinophils.