1026773-69-2Relevant academic research and scientific papers
Diastereoselective synthesis of δ-aminoacids through domino Ireland-Claisen rearrangement and michael addition
Garrido, Narciso M.,Garcia, Mercedes,Diez, David,Sanchez, M. Rosa,Sanz,Urones, Julio G.
supporting information; experimental part, p. 1687 - 1690 (2009/04/12)
A novel domino reaction-stereoselective Ireland-Clalsen rearrangement and asymmetric Michael addition-Is described. A protocol starting from Baylis-Hillman adducts 3a-f using chlral lithium amide affords optically active γ-substituted λ-aminoacids 4a-f with high diastereoselectivlties and enantioselectivities. The acid can be isolated easily from large-scale reactions and transformed to 2,3-disubstituted piperidines 11 or 2-substituted nipecotic acid derlvates 12.
