10268-80-1

Basic information

• Product Name: N-(2-aminophenyl)butanamide
• Synonyms: N-(2-aminophenyl)butanamide;OTAVA-BB 1171762
• CAS NO: 10268-80-1
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.234
• Mol File: 10268-80-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-aminophenyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-aminophenyl)butanamide(10268-80-1)
• EPA Substance Registry System: N-(2-aminophenyl)butanamide(10268-80-1)

Safety Data

• Hazardous Substances Data: 10268-80-1(Hazardous Substances Data)

Upstream product

• 339307-16-3 N-(2-nitrophenyl)butyramide 
• 106-31-0 butanoic acid anhydride 
• 95-54-5 1,2-diamino-benzene 
• 62-53-3 aniline 
• 88-74-4 2-nitro-aniline 
• 141-75-3 butyryl chloride 
• 107-92-6 butyric acid 

Downstream Products

• 1045764-86-0 C₁₂H₁₅ClN₂O₂ 

Relevant articles and documents

Coumarin-based urea-amide scaffold in ratiometric fluorescence sensing of CN?

Coumarin-based urea and urea–amide scaffolds 1–3 have been designed and synthesized for the selective and naked eye detection of cyanide ion. Of the three, compound 3 exhibits ratiometric fluorescence change selectively in the presence of CN? and validates the rationality in designing anion receptor. Upon interaction with CN?, the color of the solution of 3 in CH3CN under UV exposure becomes bright yellow, which is beneficial for its naked eye detection. Addition of CN? of ～10?4?M brings nice color change from colourless to yellow in ordinary light. The sensing event is supposed to be due to nucleophilic addition of CN? to the coumarin unit enabling intramolecular charge transfer (ICT) mechanism.

Azobenzene-diamides as Photopharmacological Ligands for Insect Ryanodine Receptor

Photoresponsive ligands are powerful tool compounds for studying receptor function with spatiotemporal resolution. However, to the best of our knowledge, such a ligand is not available for the ryanodine receptor (RyR). Herein, we present a photochromic ligand (PCL) for insect RyR by decorating chlorantraniliprole (CHL) with photoswitchable azobenzene (AB). We demonstrated that one potent ligand, named ABCHL13, shows light-induced reversible trans-cis isomerization and 3.5-fold insecticidal activity decrease toward oriental armyworm (Mythimna separata) after UV-light irradiation, that is, trans-ABCH13 has higher activity than the cis-ABCH13. ABCHL13 enables optical control over intracellular Ca2+ release in dorsal unpaired median (DUM) neurons of M. separata and American cockroach (Periplaneta americana) and cardiac function of P. americana. Our results provide a first photopharmacological toolkit that is applicable to light-dependent regulation of RyR and heart beating.

Facile synthesis of thiazoles via an intramolecular thia-Michael strategy

A mild and efficient method for the synthesis of substituted thiazoles is reported via one-pot N-desilylation, thioacylation/oxythioacylation/thiothioacylation followed by thia-Michael cycloisomerisation. This method has a general applicability to introdu