102683-26-1

Basic information

• Product Name: N-(benzyloxycarbonyl)-L-tyrosyl-D-serine methyl ester
• Synonyms: N-(benzyloxycarbonyl)-L-tyrosyl-D-serine methyl ester
• CAS NO: 102683-26-1
• Molecular Weight: 416.431
• Mol File: 102683-26-1.mol

Chemical Properties

• CAS DataBase Reference: N-(benzyloxycarbonyl)-L-tyrosyl-D-serine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(benzyloxycarbonyl)-L-tyrosyl-D-serine methyl ester(102683-26-1)
• EPA Substance Registry System: N-(benzyloxycarbonyl)-L-tyrosyl-D-serine methyl ester(102683-26-1)

Safety Data

• Hazardous Substances Data: 102683-26-1(Hazardous Substances Data)

Upstream product

• 3417-91-2 L-tyrosine methyl ester HCl 
• 501-53-1 benzyl chloroformate 
• 13512-31-7 N-(benzyloxycarbonyl)-L-tyrosine methyl ester 
• 5874-57-7 R-(-)-serine methyl ester hydrochloride 
• 1164-16-5 Z-L-Tyr-OH 
• 2104-89-4 D-serine methyl ester 

Downstream Products

• 115141-41-8 N-(benzyloxycarbonyl)-L-tyrosyl-D-serylglycyl-L-phenylalanyl-L-leucyl-O-tert-butyl-L-threonine 
• 115141-26-9 Tyr-D-Ser-Gly-Phe-Leu-Thr(O-t-Bu) 
• 115141-37-2 Cbz-Tyr-D-Ser-Gly-OMe 
• 115141-38-3 N-(benzyloxycarbonyl)-L-tyrosyl-D-serylglycine 
• 115141-36-1 Cbz-Tyr-D-Ser-OH 

Relevant articles and documents

Enzyme-catalysed Synthesis of Peptides containing D-Amino Acids

Practical procedures are described for the preparation of D-amino acid-containing dipeptides using α-chymotrypsin and the Met(O)192-modified enzyme as a catalyst.

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A series of linear conformationally constrained opioid peptides was designed in an attempt to develop highly selective and potent agonists for the δ opioid receptors.These enkephalin analogues corresponding to the general formula Tyr-D-X(OY)-Gly-Phe-Leu-T

Enzyme-Catalyzed Irreversible Formation of Peptides Containing D-Amino Acids

Procedures have been developed for the preparation of dipeptides Z-L-Tyr-D-X and Z-L-Phe-D-X using Z-L-Tyr-OMe (or Z-L-Phe-OMe) and D-amino acid esters or amides (D-X) as substrates and soluble or immobilized α-chymotrypsin as a catalyst.The formation of each of these peptides in miscible or immiscible organic solvent-water systems in a kinetically controlled approach is virtually irreversible with no side reactions or racemization.Kinetic studies indicate that D-amino acid esters are about 100 times that of water and 10percent that of L-amino acid esters as a nucleophile in deacylation reactions.The effects of pH, organic solvents, temperature, and substrate and enzyme concentrations on the yield and the stability of the enzyme in syntheses have been studied and the results compared with those in the enzyme-catalyzed formation of L-L-dipeptides.