102683-29-4

Upstream product

• 2577-94-8 L-arginine methyl ester 
• 13512-31-7 N-(benzyloxycarbonyl)-L-tyrosine methyl ester 
• 18598-71-5 L-arginine methyl ester hydrochloride 
• 22888-59-1 L-arginine methyl ester dihydrochloride 
• 102988-95-4 C₂₂H₂₅NO₇ 
• 1164-16-5 Z-L-Tyr-OH 
• 501-53-1 benzyl chloroformate 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 74-79-3 L-arginine 

Relevant academic research and scientific papers

Direct N-glycan profiling in the presence of tryptic peptides on MALDI-TOF by controlled ion enhancement and suppression upon glycan-selective derivatization

Even though the formidably laborious and time-consuming nature of oligosaccharide analysis limits certain attempts to analyze the glycosylation profile, the significant elucidation of carbohydrate modifications is largely dependent on it. Aiming to substa

A Search for Peptide Ligase: Cosolvent-Mediated Conversion of Proteases to Esterases for Irreversible Synthesis of Peptides

Serine and cysteine proteases (trypsin, chymotrypsin, papain, subtilisin) in the presence of certain concentrations of water-miscible organic solvents express no amidase activities.The esterase activities, however, remain significant.These modified enzyme

Enzyme-Catalyzed Irreversible Formation of Peptides Containing D-Amino Acids

Procedures have been developed for the preparation of dipeptides Z-L-Tyr-D-X and Z-L-Phe-D-X using Z-L-Tyr-OMe (or Z-L-Phe-OMe) and D-amino acid esters or amides (D-X) as substrates and soluble or immobilized α-chymotrypsin as a catalyst.The formation of each of these peptides in miscible or immiscible organic solvent-water systems in a kinetically controlled approach is virtually irreversible with no side reactions or racemization.Kinetic studies indicate that D-amino acid esters are about 100 times that of water and 10percent that of L-amino acid esters as a nucleophile in deacylation reactions.The effects of pH, organic solvents, temperature, and substrate and enzyme concentrations on the yield and the stability of the enzyme in syntheses have been studied and the results compared with those in the enzyme-catalyzed formation of L-L-dipeptides.

Enzyme-catalysed Synthesis of Peptides containing D-Amino Acids

Practical procedures are described for the preparation of D-amino acid-containing dipeptides using α-chymotrypsin and the Met(O)192-modified enzyme as a catalyst.