1026847-36-8

Basic information

• Product Name: (E)-1-[2-Hydroxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-3-(2-methoxy-phenyl)-propenone
• Synonyms: (E)-1-[2-Hydroxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-3-(2-methoxy-phenyl)-propenone
• CAS NO: 1026847-36-8
• Molecular Weight: 354.403
• Mol File: 1026847-36-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-1-[2-Hydroxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-3-(2-methoxy-phenyl)-propenone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-[2-Hydroxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-3-(2-methoxy-phenyl)-propenone(1026847-36-8)
• EPA Substance Registry System: (E)-1-[2-Hydroxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-3-(2-methoxy-phenyl)-propenone(1026847-36-8)

Safety Data

• Hazardous Substances Data: 1026847-36-8(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 111841-07-7 2-hydroxy-4-(tetrahydropyran-2-yloxy)acetophenone 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 686717-90-8 1-[3-(2,4-dihydroxy-phenyl)-5-(2-methoxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone 
• 108051-21-4 (E)-1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)-2-propen-1-one 

Relevant articles and documents

Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein

A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein- mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity.

Synthesis and activity of a new series of chalcones as aldose reductase inhibitors

A new series of chalcone derivatives has been synthesized and tested in vitro in order to assess their ability to inhibit aldose reductase enzyme (ALR2) and their specificity towards the target enzyme with respect to other oxidoreductases, such as aldehyde reductase, sorbitol dehydrogenase, and glutathione reductase. All the compounds display affinity for ALR2. The X-ray crystal structure of 1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)propen-1-one was determined.