102687-80-9

Upstream product

• 102687-79-6 2-Benzenesulfonyl-3-benzylamino-4,4,4-trifluoro-1-phenyl-butan-1-ol 
• 102687-72-9 (1-Benzenesulfonylmethyl-2,2,2-trifluoro-ethyl)-benzyl-amine 
• 122920-70-1 (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-yl acetate 
• 100-46-9 benzylamine 
• 850786-02-6 benzyl[3-phenyl-1-(trifluoromethyl)prop-2-ynyl]amine 
• 152338-21-1 1,1,1-trifluoro-4-phenylbut-3-en-2-yl acetate 

Relevant academic research and scientific papers

Regioselective synthesis of trifluoromethyl group containing allylic amines by palladium-catalyzed allylic amination and sequential isomerization

The palladium-catalyzed regioselective allylic amination of the α-trifluoromethyl group-substituted allyl acetate has been accomplished using Pd(OAc)2/DPPE and [Pd(π-allyl)(cod)]BF4/DPPF as catalysts. The selective formation of the γ-product was attained in the presence of Pd(OAc)2/DPPE, while the α-product was obtained using [Pd(π-allyl)(cod)]BF4/DPPF. We also succeeded in the regioselective synthesis of the enantiomerically enriched aminated product from chiral allyl acetate using Pd(OAc)2/DPPE and [Pd(π-allyl)(cod)] BF4/(S)-BINAP. Furthermore, we found that kinetic resolution had occurred during the isomerization step from the γ-type product to the α-type product by the [Pd(π-allyl)(cod)]BF4/(S)-BINAP catalyst.

Regioselective synthesis of trifluoromethyl group substituted allylic amines via palladium-catalyzed allylic amination

The palladium-catalyzed regioselective allylic amination of α-trifluoromethylated allyl acetate occurred using Pd(OAc)2/DPPE and [Pd(π-allyl)(cod)]BF4/DPPF. The selective formation of the γ-product was attained by Pd(OAc)2

Stereoselective access to substituted [(E)- or (Z)-1-(trifluoromethyl)- allyl]amines

Hydrometallation reactions, for example, hydroboration and hydroalumination, on [1-(trifluoromethyl)propargyl]amines lead stereoselectively to the corresponding [(Z)- and (E)-1-(trifluoromethyl)allyl]amines in good yields; (Z)- and (E)-allylamines with a free amino group can be obtained in good yields and excellent enantioselectivities from the chiral propargylamines. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.