1026892-41-0

Upstream product

• 167966-30-5 4-Benzhydryloxycarbonylmethyl-2,5-difluoro-benzoic acid ethyl ester 
• 1026089-57-5 4-Carboxymethyl-2,5-difluoro-benzoic acid ethyl ester 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 70775-39-2 dimethylsulfoxonium methylide 
• 1026473-13-1 4-(1-Benzhydryloxycarbonyl-vinyl)-2,5-difluoro-benzoic acid ethyl ester 

Downstream Products

• 1026412-79-2 7-(1-Benzyloxycarbonylamino-cyclopropyl)-1-(4-benzyloxy-phenyl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 1026174-43-5 7-(1-Benzyloxycarbonylamino-cyclopropyl)-1-(4-benzyloxy-phenyl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 1027897-79-5 7-(1-Benzyloxycarbonylamino-cyclopropyl)-6-fluoro-1-(2-fluoro-4-methoxy-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 1026397-16-9 7-(1-Benzyloxycarbonylamino-cyclopropyl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 1027207-96-0 7-(1-Benzyloxycarbonylamino-cyclopropyl)-6-fluoro-1-(4-methoxy-2-methyl-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 167966-40-7 7-(1-Benzyloxycarbonylamino-cyclopropyl)-6-fluoro-1-(2-fluoro-4-methoxy-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 167966-34-9 7-(1-Benzyloxycarbonylamino-cyclopropyl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 167966-41-8 7-(1-Benzyloxycarbonylamino-cyclopropyl)-6-fluoro-1-(4-methoxy-2-methyl-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 167966-33-8 3-[4-(1-Benzyloxycarbonylamino-cyclopropyl)-2,5-difluoro-phenyl]-3-oxo-propionic acid ethyl ester 
• 1026156-10-4 {1-[2,5-Difluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester 
• 135411-26-6 4-(1-Benzyloxycarbonylamino-cyclopropyl)-2,5-difluoro-benzoic acid ethyl ester 
• 167966-32-7 4-(1-Benzyloxycarbonylamino-cyclopropyl)-2,5-difluoro-benzoic acid 
• 1027839-18-4 4-(1-Ethoxycarbonyloxycarbonyl-cyclopropyl)-2,5-difluoro-benzoic acid ethyl ester 
• 1027034-17-8 4-(1-Azidocarbonyl-cyclopropyl)-2,5-difluoro-benzoic acid ethyl ester 

Relevant academic research and scientific papers

Pyridonecarboxylic acids as antibacterial agents. VIII. Synthesis and structure-activity relationship of 7-(1-aminocyclopropyl)-4-oxo-1,8-naphthyridine-3-carboxylic acids and 7-(1-aminocyclopropyl)-4-oxoquinoline-3-carboxylic acids

4-Oxo-1,8-naphthyridine- and 4-oxoquinoline-3-carboxylic acids (2a, b and 3a-l) possessing a 1-aminocyclopropyl group at the 7-position have been synthesized and evaluated for in vitro antibacterial activities. The three quinolones (3d, h, i) exhibited potent antibacterial activities against both gram-positive and gram-negative bacteria, which are comparable to those of ciprofloxacin (CPFX) and ofloxacin (OFLX). Among the three compounds, the best pharmacological and pharmacokinetic profile was obtained with 3i, an OFLX analogue, which was considerably less toxic than three reference quinolones (1, CPFX, and OFLX).