1026985-36-3

Basic information

• Product Name: 5-methyl-2-(methylethyl)phenyl 3,4,5-tribenzyloxybenzoate
• Synonyms: 5-methyl-2-(methylethyl)phenyl 3,4,5-tribenzyloxybenzoate
• CAS NO: 1026985-36-3
• Molecular Weight: 572.701
• Mol File: 1026985-36-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methyl-2-(methylethyl)phenyl 3,4,5-tribenzyloxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-(methylethyl)phenyl 3,4,5-tribenzyloxybenzoate(1026985-36-3)
• EPA Substance Registry System: 5-methyl-2-(methylethyl)phenyl 3,4,5-tribenzyloxybenzoate(1026985-36-3)

Safety Data

• Hazardous Substances Data: 1026985-36-3(Hazardous Substances Data)

Upstream product

• 70424-94-1 methyl 3,4,5-tris(benzyloxy)benzoate 
• 1486-48-2 3,4,5-tribenzyloxybenzoic acid 
• 99-24-1 methyl galloate 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 89-83-8 thymol 

Relevant articles and documents

Depigmenting activity and low cytotoxicity of alkoxy benzoates or alkoxy cinnamte in cultured melanocytes

To obtain effective and safe topical depigmenting agents, we synthesized hydroxybenzoates, alkoxybenzoates, and 3,4,5-trimethoxycinnamate containing a thymol moiety and screened then for high-level inhibitory activity against melanin synthesis in cultured melanocytes. Eight compounds were tested for their depigmenting effect and cytotoxicity using a murine melanocyte cell line. We found that 3,4,5-trialkoxybenzoates and 3,4,5-trimethoxycinnamate, synthesized by conjugating 3,4,5-trialkoxybenzoic acids and 3,4,5-trimethoxycinnmic acid with thymol, showed a potent depigmenting effect and low cytotoxicity. Compound 4h, 5-methyl-2-(methylethyl)phenyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate, showed the most potent depigmenting effect (IC50=10 μM) with low cytotoxicity (IC50=200 μM).