1026988-66-8Relevant articles and documents
Chemodivergence in enantioselective desymmetrization of diazabicycles: Ring-opening versus reductive arylation
Menard, Frederic,Lautens, Mark
, p. 2085 - 2088 (2008)
(Chemical Equation Presented) Divergent bicycle paths: A chemodivergent desymmetrization occurs after an initial enantioselective carbometalation step. The reaction brings a solution to the challenging problem of the enantioselective ring-opening of diazabicyclo-[2.2.1]heptanes to obtain arylated cyclopentenamines (see scheme, right). An alternative reaction pathway was discovered in which C-H insertion/1,4-metal migration occurs to give reductive arylation products (left).