1026995-72-1

Basic information

• Product Name: Chloro{[(1S,2S)-(+)-2-amino-1,2-diphenylethyl](pentafluorophenylsulfonyl)amido}(p-cymene)ruthenium(II), min. 90% RuCl[(S,S)-Fsdpen](p-cymene)
• Synonyms: Chloro{[(1S,2S)-(+)-2-amino-1,2-diphenylethyl](pentafluorophenylsulfonyl)amido}(p-cymene)ruthenium(II), min. 90% RuCl[(S,S)-Fsdpen](p-cymene);Chloro{[(1S,2S)-(+)-2-amino-1,2-diphenylethyl](pentafluorophenylsulfonyl)amido}(p-cymene)ruthenium(II), min. 90% RuCl[(S,S)-Fsdpen](p-cymene);Chloro{[(1S,2S)-(-)-2-aMino-1,2-diphenylethyl](pentafluorophenylsulfonyl)aMido}(p-cyMene)rutheniuM(II),90% RuCl[(S,S)-Fsdpen](p-cyMene);Chloro[[(1S,2S)-(+)-2-amino-1,2-diphenylethyl](pentafluorophenylsulfonyl)amido](p-cymene)ruthenium(II);RuCl[(S,S)-FsDPEN](p-cymene);RUTHENIUM,[N-{(1S,2S)-2-(AMINO-N)-1,2-DIPHENYLETHYL}-2,3,4,5,6-PENTAFLUOROBENZENESULFONAMIDATO-N]CHLORO[(1,2,3,4,5,6-)-1-METHYL-4-(1-METHYLETYL)BENZENE]-;[(1S,2S)-2-amino-1,2-diphenylethyl]-(2,3,4,5,6-pentafluorophenyl)sulfonylazanide:1-methyl-4-propan-2-ylbenzene:ruthenium(2+):chloride
• CAS NO: 1026995-72-1
• Molecular Formula: C30H28ClF5N2O2RuS
• Molecular Weight: 712.13600
• Product Categories: organometallic complex;Ru
• Mol File: 1026995-72-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 238-244°C
• Flash Point: >100℃
• Appearance: orange to brown/Powder
• Storage Temp.: 2-8°C
• Sensitive: air sensitive
• CAS DataBase Reference: Chloro{[(1S,2S)-(+)-2-amino-1,2-diphenylethyl](pentafluorophenylsulfonyl)amido}(p-cymene)ruthenium(II), min. 90% RuCl[(S,S)-Fsdpen](p-cymene)(CAS DataBase Reference)
• NIST Chemistry Reference: Chloro{[(1S,2S)-(+)-2-amino-1,2-diphenylethyl](pentafluorophenylsulfonyl)amido}(p-cymene)ruthenium(II), min. 90% RuCl[(S,S)-Fsdpen](p-cymene)(1026995-72-1)
• EPA Substance Registry System: Chloro{[(1S,2S)-(+)-2-amino-1,2-diphenylethyl](pentafluorophenylsulfonyl)amido}(p-cymene)ruthenium(II), min. 90% RuCl[(S,S)-Fsdpen](p-cymene)(1026995-72-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1026995-72-1(Hazardous Substances Data)

Usage

Uses

RuCl[(S,S)-fsdpen](p-cymene) can be used as a catalyst.

Upstream product

• 52462-29-0 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 
• 1026785-12-5 N-((1R,2R)-2-amino-1,2-diphenylethyl)perfluorophenylsulfonamide 

Relevant articles and documents

Ru-catalyzed asymmetric transfer hydrogenation of α-acyl butyrolactone via dynamic kinetic resolution: Asymmetric synthesis of bis-THF alcohol intermediate of darunavir

The Ru-catalyzed enantio- and diastereoselective dynamic kinetic resolution of α-(benzyloxy/benzoyloxy)acyl-γ-butyrolactones has been examined via transfer hydrogenation. Employing the in situ prepared (R,R)-Ru-FsDPEN catalyst, the transfer hydrogenation of using formic acid/triethylamine at rt gave the corresponding (S)-3-((S)-2-(benzyloxy/benzoyloxy)-1-hydroxyethyl)dihydrofuran-2(3H)-one with good to excellent diastereo- and enantioselectivity. One of the resulting hydrogenation product prepared on gram scales was utilized for the synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3–b]furan-3-ol (1), a key synthetic intermediate of various HIV protease inhibitors such as darunavir with excellent enantio- (95% ee) and diastereoselectivities (dr 95:5).

Stereogenic: Cis -2-substituted- N -acetyl-3-hydroxy-indolines via ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation

Ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation of racemic 2-substituted-N-acetyl-3-oxoindolines to cis-2-substituted-N-acetyl-3-hydroxyindolines is reported. Using the homochiral {Ru[TfDPEN](p-cymene)} catalyst with S/C = 400 in a HCO2H/Et3N mixture, up to >99.9% ee and >99:1 dr are obtained with high yields (79-98%). This method provides the first example of preparing enantiomerically pure indolines through asymmetric transfer hydrogenation (ATH).