1027073-83-1

Basic information

• Product Name: 1-[3-(4-Benzhydryl-piperazin-1-yl)-propyl]-3-imidazol-1-ylmethyl-1H-indole-7-carboxylic acid methyl ester
• Synonyms: 1-[3-(4-Benzhydryl-piperazin-1-yl)-propyl]-3-imidazol-1-ylmethyl-1H-indole-7-carboxylic acid methyl ester
• CAS NO: 1027073-83-1
• Molecular Weight: 547.7
• Mol File: 1027073-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[3-(4-Benzhydryl-piperazin-1-yl)-propyl]-3-imidazol-1-ylmethyl-1H-indole-7-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(4-Benzhydryl-piperazin-1-yl)-propyl]-3-imidazol-1-ylmethyl-1H-indole-7-carboxylic acid methyl ester(1027073-83-1)
• EPA Substance Registry System: 1-[3-(4-Benzhydryl-piperazin-1-yl)-propyl]-3-imidazol-1-ylmethyl-1H-indole-7-carboxylic acid methyl ester(1027073-83-1)

Safety Data

• Hazardous Substances Data: 1027073-83-1(Hazardous Substances Data)

Upstream product

• 312915-01-8 methyl 3-dimethylaminomethylindole-7-carboxylate 
• 68109-89-7 methyl 3-[2-(E)-(dimethylamino)ethenyl]-2-nitro-benzoate 
• 93247-78-0 methyl 1H-indole-7-carboxylate 
• 5471-82-9 methyl 3-methyl-2-nitrobenzoate 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 841-77-0 diphenylmethylpiperazine 
• 1028271-58-0 1-(3-Chloro-propyl)-3-imidazol-1-ylmethyl-1H-indole-7-carboxylic acid methyl ester 

Relevant articles and documents

Thromboxane A2 synthetase inhibitors with histamine H1-blocking activity: Synthesis and evaluation of a new series of indole derivatives

A novel series of N-substituted 3-(1H-imidazol-1-ylmethyl)indole carboxylic acid derivatives were prepared and evaluated for thromboxane A2 (TXA2) synthetase-inhibitory and histaminergic H1-blocking activity. Among the compounds synthesized, indole-6-carboxylic acid derivatives showed higher activities than the other positional isomers of carboxylic acid. 1-[3-(4- Benzhydryl-1-piperazinyl)propyl]-3-(1H-imidazol-1-ylmethyl)-1H-indole-6- carboxylic acid (12) had the strongest thromboxane synthetase inhibitory activity (IC50 = 5 x 10-8 M) and H1-blocking activity (IC50 = 8 x 10- 9 M).