1027097-82-0

Basic information

• Product Name: 2-(2,4-dimethylphenoxy)-1,4-dihydronaphthalene-1,4-dione
• Synonyms: 2-(2,4-dimethylphenoxy)-1,4-dihydronaphthalene-1,4-dione
• CAS NO: 1027097-82-0
• Molecular Weight: 278.307
• Mol File: 1027097-82-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(2,4-dimethylphenoxy)-1,4-dihydronaphthalene-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-dimethylphenoxy)-1,4-dihydronaphthalene-1,4-dione(1027097-82-0)
• EPA Substance Registry System: 2-(2,4-dimethylphenoxy)-1,4-dihydronaphthalene-1,4-dione(1027097-82-0)

Safety Data

• Hazardous Substances Data: 1027097-82-0(Hazardous Substances Data)

Upstream product

• 2065-37-4 2-bromo-1,4-naphthoquinone 
• 105-67-9 2,4-Xylenol 

Relevant articles and documents

In vitro and in silico evaluations of new aryloxy-1,4-naphthoquinones as anti-Trypanosoma cruzi agents

In the search for new therapeutic alternatives for Chagas disease, a series of six aryloxy -naphthoquinone derivatives were synthesized and evaluated in vitro against Trypanosoma cruzi epimastigotes of the Tulahuén 2, INC-5, and NINOA strains. The compoun

Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity

Taking advantage of the structural features of natural products showing anti-trypanosomatid activity, we designed and synthesized a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives. The library was obtained following a parallel approach and using readily available synthons. All the derivatives showed inhibitory activity toward either Trypanosoma or Leishmania species, with 8, 10, and 16 being the most active compounds against Trypanosoma brucei rhodesiense, Leishmania donovani, and Trypanosoma cruzi cells (IC50 = 50 nM, IC50 = 0.28 μM, and IC50 = 1.26 μM, respectively).