1027100-41-9

Basic information

• Product Name: 2-methoxy-1-[(3-methoxyphenyl)-ethynyl]-benzene
• Synonyms: 2-methoxy-1-[(3-methoxyphenyl)-ethynyl]-benzene
• CAS NO: 1027100-41-9
• Molecular Weight: 238.286
• Mol File: 1027100-41-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-methoxy-1-[(3-methoxyphenyl)-ethynyl]-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-1-[(3-methoxyphenyl)-ethynyl]-benzene(1027100-41-9)
• EPA Substance Registry System: 2-methoxy-1-[(3-methoxyphenyl)-ethynyl]-benzene(1027100-41-9)

Safety Data

• Hazardous Substances Data: 1027100-41-9(Hazardous Substances Data)

Upstream product

• 21550-06-1 1-(3-methoxyphenyl)butan-1-one 
• 40230-91-9 [(2-methoxyphenyl)ethynyl]trimethylsilane 
• 529-28-2 4-iodoanisol 
• 768-70-7 1-ethynyl-3-methoxybenzene 

Relevant articles and documents

Ligand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products

Conversion of the numerous aryl ketones into aryl electrophiles via Ar-C(O) cleavage remains a challenging yet highly desirable transformation in Sonogashira-type coupling. Herein, we report a palladium-catalyzed ligand-promoted alkynylation of unstrained aryl ketones. The protocol allows the alkynylation to be carried out in a one-pot procedure with broad functional-group tolerance and substrate scope. The potential applications of this protocol in drug discovery and chemical biology are further demonstrated by late-stage diversification of a number of pharmaceuticals and natural products. More importantly, two different biologically important fragments derived from a pharmaceutical and natural product could be connected by the consecutive alkynylation of ketones. Distinct from aryl halides in conventional Sonogashira reactions, the protocol provides a practical tool for the 1,2-bifunctionalization of aryl ketone by merging ketone-directed ortho-C-H activation with ligand-promoted ipso-Ar-C(O) alkynylation.

Block modification of rod-shaped π conjugated carbon frameworks with donor and acceptor groups toward highly fluorescent molecules: Synthesis and emission characteristics

To create organic molecules that are highly fluorescent at a longer wavelength region, we investigated the synthesis (using Pd-catalyzed cross-coupling) and photophysical properties (Φ f, λ em, τ , λ abs, and ε ) of the following π conjugated molecular rods consisting of p-phenyleneethynylene units modified by donor (OMe) and/or acceptor (CN) groups: (1) side-donor modification systems (SD systems), (2) side-acceptor modification systems (SA systems), and (3) systems consisting of a donor block and an acceptor block (BL systems). As a consequence, very high Φ f values (>0.95) were obtained for BL systems. Bathochromic shifts of λ em for the same π conjugation length were largest for BL systems. Thus we succeeded in creating highly efficient light emitters at a longer wavelength region by block modification (e.g., Φ f = 0.97, λ em = 464 nm for BL-9). Considerably intense solid emission (Φ f ～ 0.5) at a longer wavelength region (500- 560 nm) was also found for BL systems. It has been found that BL-6 and BL-8 exhibit interesting two photon absorption characteristics. This journal is The Royal Society of Chemistry.