1027103-77-0Relevant academic research and scientific papers
Microwave-promoted automated synthesis of a coumarin library
Katkevi?s,Kontijevskis,Mutule,Sūna
, p. 151 - 159 (2008/12/20)
A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible.
