1027147-48-3Relevant academic research and scientific papers
Non-peptidic Inhibitors of Human Leukocyte Elastase. 4. Design, Synthesis, and in Vitro and in Vivo Activity of a Series of β-Carbolinone-Containing Trifluoromethyl Ketones
Veale, Chris A.,Damewood, James R.,Steelman, Gary B.,Bryant, Craig,Gomes, Bruce,Williams, Joseph
, p. 86 - 97 (2007/10/02)
A novel series of human leukocyte elastase (HLE) inhibitors containing the β-carbolinone ring system are reported.The design of these trifluoromethyl ketone-based inhibitors used a combination of structural information obtained from X-ray crystallography
