1027183-04-5

Basic information

• Product Name: 4-Chlorocarbonylmethyl-1,3-dioxo-2-(3-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester
• CAS NO: 1027183-04-5
• Molecular Weight: 453.802
• Mol File: 1027183-04-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Chlorocarbonylmethyl-1,3-dioxo-2-(3-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorocarbonylmethyl-1,3-dioxo-2-(3-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester(1027183-04-5)
• EPA Substance Registry System: 4-Chlorocarbonylmethyl-1,3-dioxo-2-(3-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester(1027183-04-5)

Safety Data

• Hazardous Substances Data: 1027183-04-5(Hazardous Substances Data)

Downstream Products

• 1026822-66-1 4-Methylcarbamoylmethyl-1,3-dioxo-2-(3-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester 

Relevant articles and documents

N-substituted spirosuccinimide, spiropyridazine, spiroazetidine, and acetic acid aldose reductase inhibitors derived from isoquinoline-1,3- diones. 2

The isoquinoline-1,3-dione framework featured in our clinical candidate (1) and its congener was used as the template in the design of several new series of aldose reductase inhibitors (ARIs). These series included N'- substituted spirosuccinimide, spirop