1027186-09-9

Upstream product

• 13795-24-9 benzyl 4-nitrophenyl carbonate 
• 143192-21-6 (6-Amino-hexylamino)-acetic acid 
• 124-09-4 1,6-Hexanediamine 

Downstream Products

• 143192-43-2 [(6-Benzyloxycarbonylamino-hexyl)-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-amino]-acetic acid methyl ester 

Relevant academic research and scientific papers

Building Units for N-Backbone Cyclic Peptides. 1. Synthesis of Protected N-(ω-Aminoalkylene)amino Acids and Their Incorporation into Dipeptide Units

A variety of new amino acids which contain an ω-aminoalkylene group on the Nα-amino nitrogen were synthesized by alkylation of alkylenediamines with α-halogeno acids.The reaction proceeds with inversion of configuration; thus, optically pure products were obtained when optically active α-halogeno acids were used.The N-(ω-aminoalkylene)amino acids were protected by orthogonal protecting groups to allow their incorporation into dipeptides by the "solution" techniques and into peptides by the solid-phase peptide synthesis (SPPS) methodology.A series of dipeptide analogs of Phe-Gly, Leu-Gly, Trp-Gly, Phe-Leu, and Phe-Ala in which the nitrogen of the peptide bond is alkylated by ω-aminoalkylene chains with various lengths were prepared.These new protected N-(ω-aminoalkylene)amino acids and their derived dipeptide units may be used as building blocks for conformationally constrained N-backbone cyclic peptides.