1027199-46-7Relevant academic research and scientific papers
Efficient asymmetric synthesis of unnatural β-amino acids
Bolm,Schiffers,Dinter,Defrere,Gerlach,Raabe
, p. 1719 - 1730 (2001)
The simple and highly enantioselective methanolysis of cyclic meso-anhydrides mediated by cinchona alkaloids leads to a broad variety of dicarboxylic acid mono-methyl esters with up to 99% ee. From these products, unnatural N-protected β-amino esters can be obtained by means of Curtius degradation of the corresponding acyl azides. Subsequent cleavage of the protecting groups leads to the free β-amino acids in excellent yields. By enantiomer differentiating opening of racemic anhydrides, synthetically highly useful regioisomeric amino acid esters become readily available.
