1027259-01-3

Basic information

• Product Name: 6-nitro-1H-indazol-3-amine
• Synonyms: 6-nitro-1H-indazol-3-amine;6-Nitro-1H-indazol-3-ylamine
• CAS NO: 1027259-01-3
• Molecular Formula: C7H6N4O2
• Molecular Weight: 178
• Mol File: 1027259-01-3.mol

Chemical Properties

• Boiling Point: 485.2±25.0 °C at 760 mmHg
• Flash Point: 247.3±23.2 °C
• Appearance: /
• Density: 1.6±0.1 g/cm3
• Vapor Pressure: 0.0±1.2 mmHg at 25°C
• Refractive Index: 1.817
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11.97±0.40(Predicted)
• CAS DataBase Reference: 6-nitro-1H-indazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-nitro-1H-indazol-3-amine(1027259-01-3)
• EPA Substance Registry System: 6-nitro-1H-indazol-3-amine(1027259-01-3)

Safety Data

• Statements: 20/21/22
• Safety Statements: 7/47-36/37
• RIDADR: 2811
• Hazardous Substances Data: 1027259-01-3(Hazardous Substances Data)

Usage

Chemical Properties

Brick red solid

InChI:InChI=1S/C7H6N4O2/c8-7-5-2-1-4(11(12)13)3-6(5)9-10-7/h1-3H,(H3,8,9,10)

Upstream product

• 34667-88-4 2-fluoro-4-nitrobenzonitrile 
• 1339956-03-4 benzhydrylidene[6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl]amine 

Relevant articles and documents

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Direct access to 3-aminoindazoles by Buchwald-Hartwig C-N coupling reaction

An efficient synthesis of various N-substituted 3-aminoindazoles using Buchwald-Hartwig C-N coupling reaction is described. Several parameters were varied, including the nature of the halogen atom and the protecting group of the starting materials, as well as the effects of the catalyst system, base, solvent, and reaction time. The efficiency of microwave versus conventional heating was also compared to test the outcome of the reaction. Thus, by applying this recent knowledge about metal-catalyzed aminations, an alternative for the direct synthesis of primary 3-aminoindazoles has been provided. Georg Thieme Verlag Stuttgart. New York.

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