1027269-90-4

Usage

Uses

Used in Agricultural Applications:
2,4-dibromo-6-(trifluoromethoxy)Phenol is used as a fungicide for inhibiting the growth of microorganisms that cause plant diseases, thereby protecting crops from fungal infections.
2,4-dibromo-6-(trifluoromethoxy)Phenol is used as a pesticide to control plant pests, such as insects and mites, that can damage crops and reduce agricultural productivity.
2,4-dibromo-6-(trifluoromethoxy)Phenol is used as a herbicide to manage unwanted plant growth in agricultural fields, ensuring optimal conditions for crop cultivation.
Used in Industrial Applications:
2,4-dibromo-6-(trifluoromethoxy)Phenol is used as a biocide in industrial settings to prevent the growth of microorganisms in various systems, such as water treatment facilities and industrial equipment, thereby maintaining the efficiency and longevity of these systems.
However, it is important to note that the use of 2,4-dibromo-6-(trifluoromethoxy)Phenol can pose environmental and health risks, as it is toxic to aquatic organisms and may have harmful effects on human health if not properly handled and managed. Therefore, strict regulations and safety measures should be implemented to minimize these risks.

Upstream product

• 32858-93-8 2-(trifluoromethoxy)phenol 

Downstream Products

• 1124148-03-3 C₈H₅Br₂F₃O₂ 

Relevant academic research and scientific papers

THIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS

The invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, which are antagonist of the CXCR3 chemokine receptor useful for the treatment or prevention of pathogenic inflammatory processes, autoimmune diseases or graft rejection processes. Methods of use and pharmaceutical compositions are also encompassed.

Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC

Deacetylation of uridyldiphospho-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine by LpxC is the first committed step in the Pseudomonas aeruginosa biosynthetic pathway to lipid A; homologous enzymes are found widely among Gram-negative bacteria. As an essential enzyme for which no inhibitors have yet been reported, the P. aeruginosa LpxC represents a highly attractive target for a novel antibacterial drug. We synthesized several focused small-molecule libraries, each composed of a variable aromatic ring, one of four heterocyclic/spacer moieties, and a hydroxamic acid and evaluated the LpxC inhibition of these compounds against purified P. aeruginosa enzyme. To ensure that the in vitro assay would be as physiologically relevant as possible, we synthesized a tritiated form of the specific P. aeruginosa glycolipid substrate and measured directly the enzymatically released acetate. Several of our novel compounds, predominantly those having fluorinated substituents on the aromatic ring and an oxazoline as the heterocyclic moiety, demonstrated in vitro IC50 values less than 1 μM. We now report the synthesis and in vitro evaluation of these P. aeruginosa LpxC inhibitors.