1027273-90-0Relevant academic research and scientific papers
Catalytic asymmetric synthesis of an HIV integrase inhibitor
Zhong, Yong-Li,Krska, Shane W.,Zhou, Hua,Reamer, Robert A.,Lee, Jaemoon,Sun, Yongkui,Askin, David
supporting information; experimental part, p. 369 - 372 (2009/09/06)
(Chemical Equation Presented) An efficient synthesis of HIV integrase inhibitor (S)-(-)-1 via a unique asymmetric hydrogenation of a mixture of imines/enamine 5a-5b/5c is described. Hydrogenation of the imines/enamine by a Rh(I)-Josiphos complex afforded
PROCESS FOR ASYMMETRIC SYNTHESIS OF HEXAHYDROPYRIMIDO[1,2-A] AZEPINE-2-CARBOXAMIDES AND RELATED COMPOUNDS
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Page/Page column 33-34, (2010/11/08)
Processes for asymmetric synthesis of 1O(S)-amino-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepine-2-carboxamides and related compounds are disclosed. The enantiomerically enriched carboxamides are useful as HIV integrase inhibitors and thus are useful for treating HIV infection and AIDS.
