1027290-06-7

Upstream product

• 117833-92-8 (4S)-3-benzyloxycarbonyl-2,2-dimethyloxazolidine-4-carbaldehyde 
• 321658-31-5 (R)-3-(benzyloxycarbonyl)-2,2-dimethyl-4-<(E)-2-carbomethoxyvinyl>oxazolidine 
• 117833-99-5 N-benzyloxycarbonyl 4(S)-(1'-methoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine 
• 500109-19-3 (R)-4-((E)-2-Carboxy-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 

Downstream Products

• 321658-32-6 (R)-4-((E)-4-tert-Butoxycarbonylamino-4-ethoxycarbonyl-3-oxo-but-1-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 500109-20-6 (R)-4-[(E)-4-tert-Butoxycarbonylamino-3-oxo-4-(2-oxo-propylcarbamoyl)-but-1-enyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Concise route to α-acylamino-β-keto amides: Application to the synthesis of a simplified azinomycin A analogue

Condensation of acid chlorides (alkyl, aryl or heteroaryl) with N,N′-dialkyl α-acylamino malonamides in the presence of magnesium ethoxide provides a direct route to α-acylamino-β-keto amides in moderate to good yields (46-95%). Using this method, a conci

A synthetic azinomycin analogue with demonstrated DNA cross-linking activity: Insights into the mechanism of action of this class of antitumor agent

An efficient synthesis of simplified azinomycin A and B analogues 1 and 2 (see picture) is described, and it is demonstrated that only 1, bearing both the epoxide and aziridine, induces interstrand cross-links in double-stranded DNA. Remarkably, a compoun