1027294-28-5Relevant academic research and scientific papers
Decarboxylative Cross-Electrophile Coupling of N-Hydroxyphthalimide Esters with Aryl Iodides
Huihui, Kierra M. M.,Caputo, Jill A.,Melchor, Zulema,Olivares, Astrid M.,Spiewak, Amanda M.,Johnson, Keywan A.,Dibenedetto, Tarah A.,Kim, Seoyoung,Ackerman, Laura K. G.,Weix, Daniel J.
supporting information, p. 5016 - 5019 (2016/05/19)
A new method for the decarboxylative coupling of alkyl N-hydroxyphthalimide esters (NHP esters) with aryl iodides is presented. In contrast to previous studies that form alkyl radicals from carboxylic acid derivatives, no photocatalyst, light, or arylmetal reagent is needed, only nickel and a reducing agent (Zn). Methyl, primary, and secondary alkyl groups can all be coupled in good yield (77% ave yield). One coupling with an acid chloride is also presented. Stoichiometric reactions of (dtbbpy)Ni(2-tolyl)I with an NHP ester show for the first time that arylnickel(II) complexes can directly react with NHP esters to form alkylated arenes.
PIPERAZINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLU5 RECEPTORS
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Page/Page column 71, (2013/07/05)
This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. R1, R2, R3, R4, Q have meanings given in the description.
Towards a new generation of potential antipsychotic agents combining D 2 and 5-HT1A receptor activities
Cuisiat, Stephane,Bourdiol, Nathalie,Lacharme, Vincent,Newman-Tancredi, Adrian,Colpaert, Francis,Vacher, Bernard
, p. 865 - 876 (2007/10/03)
We report the discovery and the synthesis of novel, potential antipsychotic compounds combining potent dopamine D2 receptor antagonist and serotonin 5-HT1A receptor agonist properties in the same molecule. We describe the structure-a
