1027309-84-7

Basic information

• Product Name: (S)-2-{(R)-2-[3-((S)-2-Benzyloxycarbonylamino-2-phenyl-acetylamino)-2-oxo-pentanoylamino]-4-methyl-pentanoylamino}-3-methyl-butyric acid tert-butyl ester
• CAS NO: 1027309-84-7
• Molecular Weight: 666.815
• Mol File: 1027309-84-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-{(R)-2-[3-((S)-2-Benzyloxycarbonylamino-2-phenyl-acetylamino)-2-oxo-pentanoylamino]-4-methyl-pentanoylamino}-3-methyl-butyric acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-{(R)-2-[3-((S)-2-Benzyloxycarbonylamino-2-phenyl-acetylamino)-2-oxo-pentanoylamino]-4-methyl-pentanoylamino}-3-methyl-butyric acid tert-butyl ester(1027309-84-7)
• EPA Substance Registry System: (S)-2-{(R)-2-[3-((S)-2-Benzyloxycarbonylamino-2-phenyl-acetylamino)-2-oxo-pentanoylamino]-4-methyl-pentanoylamino}-3-methyl-butyric acid tert-butyl ester(1027309-84-7)

Safety Data

• Hazardous Substances Data: 1027309-84-7(Hazardous Substances Data)

Upstream product

• 135219-72-6 (S)-2-((R)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-butyric acid tert-butyl ester 
• 219323-43-0 (S)-ethyll 2-(benzyloxycarbonylamino)-2-phenylacetate 
• 501-53-1 benzyl chloroformate 
• 59410-82-1 (S)-α-phenylglycine ethyl ester hydrochloride 
• 5491-18-9 (S)-N-(benzyloxycarbonyl)phenylglycine 
• 13518-40-6 L-valine tert-butylester hydrochloride 
• 28862-79-5 Z-D-Leu-OH 

Relevant articles and documents

Poststatin, a new inhibitor of prolyl endopeptidase. V. Endopeptidase inhibitory activity of poststatin analogues

Thirty analogues of poststatin were synthesized, and their inhibitory activities against prolyl endopeptidase, human leukocyte elastase and cathepsin B were measured. The α-ketone was essential and the S configuration was preferable to the R configuration in the β-substituted-β-amino-α-oxopropionic acid moiety of poststatin analogues for endopeptidase inhibitory activity. The analogue in which the D-leucine residue of poststatin was replaced by L-leucine showed strong inhibitory activity to cathepsin B. Introduction of an aromatic group into the P4 position and proline into the P2 position increased inhibitory activity to elastase. Benzyloxycarbonyl-L-homophenylalanyl-(RS)-3-amino-2-oxovaleryl-D- leucyl-L-valine was about 6 times more active to prolyl endopeptidase than natural poststatin.