1027339-92-9Relevant academic research and scientific papers
Synthesis and biological evaluation of 5,7-diaryl-4,4-dimethyl-4,5,6,7- tetrahydropyridino[3,4-d]-1,2,3-thiadiazoles
Gopalakrishnan,Thanusu,Kanagarajan
, p. 392 - 401 (2007)
New 5,7-diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3- thiadiazoles 23-27 are synthesized, characterized by melting point, elemental analysis, magnetic spectroscopy (MS), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) (1H and 13C) spectra and evaluated for their in vitro antibacterial and antifungal activities. Compounds 23-27 are more potent against Gram-positive bacterial strains, namely Staphylococcus aureus and β-Haemolytic streptococcus. However compounds 23-27 possess potent activity against Klebsiella pneumonia, a Gram-negative bacterial strain, compared to the standard drug used, ciprofloxacin. In general, all the synthesized compounds exert a wide range of modest in vitro antifungal activity against Rhizopus and Microsporum gypsuem than the standard drug, fluconazole.
