102734-22-5Relevant academic research and scientific papers
Stereoselective intramolecular nitrone cycloaddition in the synthesis of Lasubine II.
Hoffmann, Reinhard W.,Endesfelder, Andreas
, p. 1823 - 1836 (2007/10/02)
The intramolecular cycloaddition of α-substituted N-alkenylnitrones 2 leads to the 7-oxa-1-azanorbornanes 6,7, and 8 with a selectivity of ca. 80percent in favor of the exo,exo-disubstituted compound 6.The latter can be reduced to give the all-cis-2,6-disubstituted 4-hydroxypiperidines 4 which are key compounds for the synthesis of certain alkaloids as demonstrated by the synthesis of lasubine II.
