1027341-12-3Relevant academic research and scientific papers
Rational Use of Heterogeneous Data in Quantitative Structure-Activity Relationship (QSAR) Modeling of Cyclooxygenase/Lipoxygenase Inhibitors
Lagunin, Alexey A.,Geronikaki, Athina,Eleftheriou, Phaedra,Pogodin, Pavel V.,Zakharov, Alexey V.
, (2019/03/02)
Numerous studies have been published in recent years with acceptable quantitative structure-activity relationship (QSAR) modeling based on heterogeneous data. In many cases, the training sets for QSAR modeling were constructed from compounds tested by dif
2-thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action
Geronikaki,Eleftheriou,Vicini,Alam,Dixit,Saxena
experimental part, p. 5221 - 5228 (2009/07/01)
SHP-2, a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene, mediates cell signaling by growth factors and cytokines via the RAS/MAP kinase pathway. Somatic mutations in PTPN11 gene account for approximately 18% of juvenile myelomonocytic
