1027343-75-4

Usage

Uses

Used in Medicinal Chemistry:
(1R,2R,3R,5R)-(2-TERT-BUTOXYCARBONYLAMINO)-6,6-DIMETHYLBICYCLO[3.1.1]HEPTAN-3-CARBOXYLIC ACID is used as a building block for the synthesis of more complex molecules in medicinal chemistry. Its chiral nature and functional groups may contribute to the development of new drugs with specific biological activities.
Used in Pharmaceutical Applications:
(1R,2R,3R,5R)-(2-TERT-BUTOXYCARBONYLAMINO)-6,6-DIMETHYLBICYCLO[3.1.1]HEPTAN-3-CARBOXYLIC ACID is used as a potential pharmaceutical candidate due to its structure and functional groups. It may be further modified or used as a precursor in the development of new drugs with therapeutic properties.

Upstream product

• 1027343-52-7 (1R,2R,5R,7R)-2-amino-6,6-dimethylbicyclo[3.3.1]heptane-3-carboxylic acid hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1027343-76-5 ethyl (2S,1'R,2'R,3'R,5'R)-2-[(2'-tert-butoxycarbonylamino)-6',6'-dimethylbicyclo[3.3.1]heptane-3'-carbonyl]amino-3-phenylpropionate 

Relevant academic research and scientific papers

Regio- and stereoselective synthesis of constrained enantiomeric β-amino acid derivatives

Chlorosulfonyl isocyanate addition to (-)- and (+)-apopinene furnished monoterpene-fused β-lactams in highly regio- and stereospecific reactions. β-Lactams 5 and 13 exhibited reactivities similar to those of the cycloalkane-fused analogs and were easily c

CHIRAL CYCLIC ?-AMINO ACIDS AND THEIR DERIVATES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE OF SUCH COMPOUNDS

The invention relates to chiral cyclic β-amino acids of Formula (I) and their salts formed with pharmaceutically acceptable acids or bases, wherein the main meanings of the substituents are as follows: R stands for C1-4 Alk; X stands for -COOH, -CONH2, -CONH(C1-4 Alk), -CON(C1-4 Alk)2, -COO(C1-4 Alk), -COPhe-O-(C1-4 Alk) or -CH2OH; Y stands for -NH2, -NHBoc, -NHFmoc, -NH(C1-4 Alk), -N(C1-4 Alk)2, -NHCH2Ph, or Ar-NH-C(=X0)-N(R0)- wherein Ar stands for a phenyl group substituted by C1-4 alkoxy or halogen, X0 stands for O or S, and R0 stands for hydrogen or benzyl; and X + Y stands for -CONH- vagy -CON(Boc)-; with the proviso that when X stands for -COOH, then Y may be only different from -NH2. The invention also relates to pharmaceutical compositions having multidrug-resistance reversing effect that contain one or more compound(s) of Formula (I) or a salt thereof and inert pharmaceutical carriers and/or auxiliary agents. The invention also relates to carboxylic acids of Formula (XX) and their salts.