102735-44-4Relevant academic research and scientific papers
Hydrogen bonds as structural directive towards unusual polynuclear complexes: synthesis, structure, and magnetic properties of copper(II) and nickel(II) complexes with a 2-aminoglucose ligand
Burkhardt, Anja,Spielberg, Eike T.,Simon, Sascha,Goerls, Helmar,Buchholz, Axel,Plass, Winfried
, p. 1261 - 1271 (2009)
The reaction of benzyl 2-amino-4,6-O-benzylidene-2-deoxy-α-D- glucopyranoside (HL) with the metal salts Cu(ClO4) 2·6H2O and Ni-(NO3)2· 6H2O affords via self-assembly a tetranuclear μ4- hydroxido bridged copper(II) complex [(μ4-OH)Cu 4(L)4-(MeOH)3(H2O)](ClO 4)3 (1) and a trinuclear alcoholate bridged nickel(II) complex [Ni3(L)5(HL)]NO3 (2), respectively. Both complexes crystallize in the acentric space group P21. The X-ray crystal structure reveals the rare (μ4-OH)Cu4O 4 core for complex 1 which is μ2-alcoholate bridged. The copper(II) ions possess a distorted square-pyramidal geometry with an [NO4] donor set. The core is stabilized by hydrogen bonding between the coordinating amino group of the glucose backbone and the benzylidene protected oxygen atom O4 of a neighboring {Cu(L)} fragment as hydrogen-bond acceptor. For complex 2 an [N4O2] donor set is observed at the nickel(II) ions with a distorted octahedral geometry. The trinuclear isosceles Ni3 core is bridged by μ3-alcoholate O3 oxygen atoms of two glucose ligands. The two short edges are capped by μ2-alcoholate O3 oxygen atoms of the two ligands coordinated at the nickel(II) ion at the vertex of these two edges. Along the elongated edge of the triangle a strong hydrogen bond (244 pm) between the O3 oxygen atoms of ligands coordinating at the two relevant nickel(II) ions is observed. The coordinating amino groups of the these two glucose ligands are involved in additional hydrogen bonds with O4 oxygen atoms of adjacent ligands further stabilizing the trinuclear core. The carbohydrate backbones in all cases adopt the stable 4C1 chair conformation and exhibit the rare chitosan-like trans-2,3-chelation. Temperature dependent magnetic measurements indicate an overall antiferromagnetic behavior for complex 1 with J1 = -260 and J2 = -205 cm-1 (g = 2.122). Compound 2 is the first ferromagnetically coupled trinuclear nickel(II) complex with JA = 16.4 and JB = 11.0 cm-1 (g1,2 = 2.183, g3 = 2.247). For the high-spin nickel(II) centers a zero-field splitting of D1,2 = 3.7 cm-1 and D3 = 1.8 cm-1 is observed. The S = 3 ground state of complex 2 is consistent with magnetization measurements at low temperatures.
NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF
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, (2019/01/04)
The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof; wherein R1 and R2 both are hydrogen; or R1 is hydrogen and R2 is alkyl or aryl; or R1 is alkyl or aryl and R2 is hydrogen; or R1 and R2 both are alkyl or aryl (same or different groups); wherein alkyl group constitute C1-C6 alkyl or higher (both linear and branched) with or without heteroatoms; and aryl group constitute phenyl, substituted phenyl, heteraryl, arylalkyl and polynuclear aromatics. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.
NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF
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, (2017/06/30)
The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof. R = alkyl (both linear and branched), aryl, substituted aryl, alkoxy alkyl Wherein, R can be both linear and branched alkyl, aryl, substituted aryl and alkoxy alkyl. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.
