1027356-81-5Relevant articles and documents
Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors
Huang, Hui,Hutta, Daniel A.,Hu, Huaping,DesJarlais, Renee L.,Schubert, Carsten,Petrounia, Ioanna P.,Chaikin, Margery A.,Manthey, Carl L.,Player, Mark R.
, p. 2355 - 2361 (2008/09/20)
A series of pyrimidinopyridones has been designed, synthesized and shown to be potent and selective inhibitors of the FMS tyrosine kinase. Introduction of an amide substituent at the 6-position of the pyridone core resulted in a significant potency increase. Compound 24 effectively inhibited in vivo LPS-induced TNF in mice greater than 80%.
