1027357-26-1Relevant academic research and scientific papers
Pyrido[2,3-d]pyrimidin-5-ones: A novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors
Huang, Hui,Hutta, Daniel A.,Rinker, James M.,Hu, Aping,Parsons, William H.,Schubert, Carsten,Desjarlais, Renee L.,Crysler, Carl S.,Chaikin, Margery A.,Donatelli, Robert R.,Chen, Yanmin,Cheng, Deping,Zhou, Zhao,Yurkow, Edward,Manthey, Carl L.,Player, Mark R.
experimental part, p. 1081 - 1099 (2010/01/07)
A series of pyrido[2,3-d]pyrimidin-5-ones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). FMS inhibitors may be useful in treating rheumatoid arthritis and other chronic infla
5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE
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Page/Page column 106, (2008/12/05)
The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a salt, stereoisomer, tautomer, crystalline, polymorph, amorphous, solvate, hydrate, ester, prodrug or metabolite form thereof, wherein A, Y, Z, R101 and R200 are described in the specification.
