1027379-57-2Relevant academic research and scientific papers
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility
Nieman, James A.,Nair, Sajiv K.,Heasley, Steven E.,Schultz, Brenda L.,Zerth, Herbert M.,Nugent, Richard A.,Chen, Ke,Stephanski, Kevin J.,Hopkins, Todd A.,Knechtel, Mary L.,Oien, Nancee L.,Wieber, Janet L.,Wathen, Michael W.
supporting information; experimental part, p. 3039 - 3042 (2010/07/03)
A series of C-2 pyrroloquinoline analogs designed to improve aqueous solubility were examined for herpesvirus polymerase and antiviral activity. Several analogs were identified that maintained the antiviral activity of the previous development candidate against HCMV, HSV-1 and VZV, but with significantly improved aqueous solubility.
