1027385-29-0Relevant academic research and scientific papers
The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors
Cox, Jason M.,Chu, Hong D.,Kuethe, Jeffrey T.,Gao, Ying-Duo,Scapin, Giovanna,Eiermann, George,He, Huaibing,Li, Xiaohua,Lyons, Kathryn A.,Metzger, Joseph,Petrov, Aleksandr,Wu, Joseph K.,Xu, Shiyao,Sinha-Roy, Ranabir,Weber, Ann E.,Biftu, Tesfaye
, p. 2622 - 2626 (2016/05/09)
Novel potent and selective 5,6,5- and 5,5,6-tricyclic pyrrolidine dipeptidyl peptidase IV (DPP-4) inhibitors were identified. Structure-activity relationship (SAR) efforts focused on improving the intrinsic DPP-4 inhibition potency, increasing protease se
TRICYCLIC HETEROAROMATIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
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Page/Page column 49, (2008/12/05)
The present invention is directed to novel substituted tricyclic heteroaromatic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
