1027406-50-3

Upstream product

• 103-71-9 phenyl isocyanate 
• 90543-03-6 4,5,6,7-Tetrahydro-2-(triphenylphosphoranylidenamino)benzothiophen-3-carbonsaeure-ethylester 

Downstream Products

• 863917-73-1 C₃₄H₂₉N₄OPS 
• 863917-84-4 2-mercapto-3-phenyl-1,2,4-triazolo[1,5-a]-6,7,8,9-tetrahydro[b]thieno[2,3-d]pyrimidin-10-one 
• 168280-54-4 3-amino-2-phenylamino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 

Relevant academic research and scientific papers

New efficient synthesis of 6,7,8,9-tetrahydro-benzothieno[2,3-d]-1,2,4- triazolo[1,5-a]pyrimidin-10(3H)-ones via a tandem aza-Wittig/heterocumulene- mediated annulation

The carbodiimides 2, obtained from aza-Wittig reactions of iminophosphorane 1 with aromatic isocyanates, reacted with hydrazine to give selectively 3-amino-2-arylamino-5,6,7,8-tetrahydro-benzothieno[2,3-d]pyrimidin-4(3H)-ones 4. Reactions of 4 with triphenylphosphine, hexachloroethane and Et3N produced iminophosphoranes 5. A tandem aza-Wittig reaction of iminophosphorane 5 with isocyanate, acyl chloride or CS2 generated 6,7,8,9-tetrahydro- benzothieno[2,3-d]-1,2,4-triazolo[1,5-a]pyrimidin-10(3H)-ones 7, 9 or 11 in satisfactory yields. Georg Thieme Verlag Stuttgart.

New Efficient Synthesis of 2-Substituted 5,6,7,8-Tetrahydro-benzo-thieno[2, 3-d]pyrimidin-4(3H)-ones

The carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates, reacted with secondary amines to give 2-dialkylamino-5,6,7,8-tetrahydro-benzothieno[2,3-d]pyrimidin-4(3H)-ones 6 in presence of catalytic EtO-Na+. Reactions of 4 with phenols or ROH in presence of catalytic K2CO3 or RO -Na+ gave 2-aryl(alkyl)oxy-5,6,7,8-tetrahydro- benzothieno[2,3-d]pyrimidin-4(3H)-ones 6 in satisfactory yields. The effects of the nucleophiles on cyclization have been investigated.