1027415-45-7Relevant articles and documents
Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents
Knutsen, Lars J. S.,Andersen, Knud Erik,Lau, Jesper,Lundt, Behrend F.,Henry, Rodger F.,Morton, Howard E.,N?rum, Lars,Petersen, Hans,Stephensen, Henrik,Suzdak, Peter D.,Swedberg, Michael D. B.,Thomsen, Christian,S?rensen, Per O.
, p. 3447 - 3462 (2007/10/03)
(3R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid 1 (tiagabine, Gabitril) is a potent and selective γ-aminobutyric acid (GABA) uptake inhibitor with proven anticonvulsant efficacy in humans. This drug, which has a unique mechanism