1027421-36-8

Basic information

• Product Name: tert-Butyl-(3-iodo-phenyl)-carbodiimide
• CAS NO: 1027421-36-8
• Molecular Weight: 300.142
• Mol File: 1027421-36-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-Butyl-(3-iodo-phenyl)-carbodiimide(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl-(3-iodo-phenyl)-carbodiimide(1027421-36-8)
• EPA Substance Registry System: tert-Butyl-(3-iodo-phenyl)-carbodiimide(1027421-36-8)

Safety Data

• Hazardous Substances Data: 1027421-36-8(Hazardous Substances Data)

Upstream product

• 626-01-7 3-Iodoaniline 
• 3125-73-3 3-iodophenyl isothiocyanate 

Relevant articles and documents

Synthesis and structure-activity relationships of novel phenylcyanoguanidine derivatives as potassium channel openers

3,5-Di-substituted phenylcyanoguanidine derivatives with halogen, cyano, and/or nitro groups at the 3- and 5-positions of the benzene ring exhibited very strong smooth muscle relaxation activity in vitro, as compared to pinacidil. Among them, N-(3-chloro-5-cyanophenyl)-N'-cyano-N''-tert- pentylguanidine (5s) showed 27-fold more potent activity than pinacidil, and exhibited a stronger and more lasting antihypertensive effect than pinacidil by oral administration to spontaneously hypertensive rats. We propose a new pharmacophore model in which the essential factors for binding to the potassium channel are an NH and a bulky alkyl group.