1027423-81-9Relevant articles and documents
Synthesis of a chiral amino acid with bicyclo[1.1.1] pentane moiety and its incorporation into linear and cyclic antimicrobial peptides
Pritz, Stephan,Paetzel, Michael,Szeimies, Guenter,Dathe, Margitta,Bienert, Michael
, p. 1789 - 1794 (2007)
The synthesis of the lipophilic chiral amino acid 1 bearing the bicyclo[1.1.1]pentane moiety is described. Linear and cyclic hexapeptides of the type Arg-Arg-Xaa-Yaa-Arg-Phe containing 1 instead of one or two tryptophan residues are prepared by solid phase peptide synthesis and the antimicrobial and hemolytic activity of the peptides obtained are discussed. This journal is The Royal Society of Chemistry.