1027554-59-1

Upstream product

• 176963-22-7 3,4,5-Trimethoxy-N-(3-methoxy-2-methoxymethoxy-6-methyl-phenyl)-benzamide 
• 176963-25-0 6-Methoxy-7-methoxymethoxy-2-(3,4,5-trimethoxy-phenyl)-1H-indole 
• 176963-19-2 3-methoxy-2-(methoxymethoxy)-6-methylaniline 
• 111726-42-2 1-methoxy-2-(methoxymethoxy)-4-methylbenzene 
• 1195-09-1 5-methyl-2-methoxyphenol 
• 1026735-31-8 6-Methoxy-7-methoxymethoxy-2-(3,4,5-trimethoxy-phenyl)-1H-indole-3-carbaldehyde 

Downstream Products

• 176963-28-3 1-Ethyl-6-methoxy-7-methoxymethoxy-3-methyl-2-(3,4,5-trimethoxy-phenyl)-1H-indole 
• 1026643-94-6 1-Ethyl-7-hydroxy-6-methoxy-3-methyl-2-(3,4,5-trimethoxy-phenyl)-1H-indole-4-carbaldehyde 
• 176963-31-8 1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-(3,4,5-trimethoxyphenyl)indole-4-carbaldehyde 
• 1025886-60-5 (E)-3-[1-Ethyl-6-methoxy-7-methoxymethoxy-3-methyl-2-(3,4,5-trimethoxy-phenyl)-1H-indol-4-yl]-2-methyl-acrylic acid 
• 1027569-89-6 (E)-3-[1-Ethyl-6-methoxy-7-methoxymethoxy-3-methyl-2-(3,4,5-trimethoxy-phenyl)-1H-indol-4-yl]-2-methyl-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Hydroxyindole derivatives as inhibitors of IL-1 generation. II. Synthesis and pharmacological activities of (E)3-(7-hydroxy-6-methoxyindole-4-yl)-2-methylpropenoic acid derivatives

A series of (E)-3-(7-hydroxy-6-methoxyindole-4-yl)-2-methylpropenoic acid derivatives was prepared and the inhibitory activities of its members on IL-1 generation were evaluated in an in vitro system using exudate cells from the rat carboxy-methyl cellulose (CMC) induced air-pouch model. All the compounds in this new series were found to be inhibitors of IL-1 generation. In particular, the methoxy-substituted 2-phenyl compounds 28d-f were the most potent inhibitors of IL-1 generation (eg, 28d: IC50 = 0.8 μ,M). The compounds in this series also inhibited IL-1α and IL-1β generations in an in vitro system using human monocytes stimulated with LPS (eg, 28b: IC50 = 1.4 μM (IL-1α) and 0.9 μM (IL-1β)).