1027576-53-9

Upstream product

• 220236-96-4 [2-Chloro-1,2-dimethyl-3-phenyl-prop-(Z)-ylidene]-isopropyl-amine 
• 78827-36-8 [2-Chloro-1-methyl-prop-(E)-ylidene]-isopropyl-amine 
• 179952-84-2 (2-Benzyl-1-methoxy-2-methyl-cyclopropyl)-isopropyl-amine 

Relevant academic research and scientific papers

Synthesis of 4,4-disubstituted β-lactams by regiospecific electrophile- and silver-induced ring expansion of 2,2-disubstituted 1-methoxycyclopropylamines

2,2-Disubstituted 1-methoxycyclopropylamines underwent regiospecific ring expansion to 1,4,4-trisubstituted 2-azetidinones by N-chlorination with tert-butyl hypochlorite and subsequent rearrangement with silver tetrafluoroborate. Upon thermolysis, 4,4-disubstituted β-lactams suffer a characteristic ring opening to afford β,γ-unsaturated carboxylic amides. The reduction of 1,4,4-trisubstituted 2-azetidinones with lithium aluminum hydride afforded 1,2,2-trisubstituted azetidines.