1027588-01-7

Basic information

• Product Name: Acetic acid 2-[5-(3-hydroxy-3-o-tolyl-prop-1-ynyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-ethyl ester
• Synonyms: Acetic acid 2-[5-(3-hydroxy-3-o-tolyl-prop-1-ynyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-ethyl ester
• CAS NO: 1027588-01-7
• Molecular Weight: 372.378
• Mol File: 1027588-01-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetic acid 2-[5-(3-hydroxy-3-o-tolyl-prop-1-ynyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 2-[5-(3-hydroxy-3-o-tolyl-prop-1-ynyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-ethyl ester(1027588-01-7)
• EPA Substance Registry System: Acetic acid 2-[5-(3-hydroxy-3-o-tolyl-prop-1-ynyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-ethyl ester(1027588-01-7)

Safety Data

• Hazardous Substances Data: 1027588-01-7(Hazardous Substances Data)

Upstream product

• 78097-08-2 1-<(2-acetoxyethoxy)methyl>-5-iodouracil 
• 139416-71-0 1-(o-tolyl)prop-2-yn-1-ol 

Downstream Products

• 249509-38-4 1-[(2-acetoxyethoxy)methyl]-5-(o-toluoylethynyl)uracil 

Relevant articles and documents

5-(Acylethynyl)uracils, 5-(Acylethynyl)-2'-deoxyuridines and 5- (Acylethynyl)-1-(2-hydroxyethoxy)methyluracils. Their synthesis, antiviral and cytotoxic activities

5-(acylethynyl)uracils 4 were synthesized from 5-iodo-2,4- dimethoxypyrimidine 1 through a palladium-catalyzed reaction with acetylenic carbinols 5, subsequent oxidation with manganese dioxide in dichloromethane, demethylation with 6 N hydrochloric acid, followed by treatment with sodium hydroxide in 95% ethanol. The corresponding 5-acylethynyl-2'-deoxyuridines 9 and 5-acylethynyl-1-(2hydroxyethoxy-methyl)uracils 13 were synthesized following a similar procedure. The 5-acylethynyluracils 4 were cytotoxic against murine L1210 and human T-lymphocyte (Molt 4/C8, CEM) cells. The 2'- deoxyuridine derivatives 9 were less cytotoxic; however the acyclonucleosides 13 were as active as the free bases 4. The compounds did not have antiviral activities at subtoxic concentrations.