1027627-33-3Relevant academic research and scientific papers
DBU-promoted facile, chemoselective cleavage of acetylenic TMS group
Yeom, Chang-Eun,Mi, Jeong Kim,Choi, Whail,Kim, B. Moon
, p. 565 - 568 (2008)
Acetylenic trimethylsilyl (TMS) groups were efficiently removed using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). With either 1.0 or even 0.1 equivalents of DBU, smooth desilylation of various terminal acetylenic TMS groups was accomplished selectively in the presence of alkyl silyl ethers and other base-labile groups. Furthermore, more sterically hindered terminal acetylenic silyl groups such as TBDMS and TIPS remained intact under these conditions. Georg Thieme Verlag Stuttgart.
