102771-26-6 Hazards Identification
Pictogram(s):
Signal:
Warning
GHS Hazard Statements:
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes:
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories:
Skin Irrit. 2 (100%)
Eye Irrit. 2 (100%)
STOT SE 3 (100%)
102771-26-6 Usage
Uses
Used in Pharmaceutical Industry:
GYKI 52466 HYDROCHLORIDE is used as a therapeutic agent for the treatment of cocaine addiction. It works by blocking the excessive stimulation of AMPA receptors in the brain, which is associated with the rewarding effects of cocaine use. This action helps to reduce the cravings and the reinforcing effects of cocaine, making it a promising candidate for addiction treatment.
Biological Activity
Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, ~ 450 and >> 50 μ M for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset? . Also available as part of the Kainate Receptor Tocriset? .
Check Digit Verification of cas no
The CAS Registry Mumber 102771-26-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,7,7 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 102771-26:
(8*1)+(7*0)+(6*2)+(5*7)+(4*7)+(3*1)+(2*2)+(1*6)=96
96 % 10 = 6
So 102771-26-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H
102771-26-6Relevant academic research and scientific papers
A simple and efficient synthesis of GYKI 52466 and GYKI 52895
Zappala, Maria,Grasso, Silvana,Micale, Nicola,Polimeni, Santina,De Micheli, Carlo
, p. 527 - 533 (2007/10/03)
The synthesis of 1-(4-aminophenyl)-4-methyl-7,8-methylene-dioxy-5H-2,3-benzodiazepine (GYKI 52466, 1), the prototype of a series of noncompetitive AMPA receptor antagonists, and its 3,4-dihydroderivative (GYKI 52895, 2) is described. The title compounds have been prepared starting from safrole through a quite effective procedure.
5H-2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same
-
, (2008/06/13)
The invention relates to new 5H-2,3-benzodiazepine derivatives and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. The new 5H-2,3-benzodiazepine derivatives of the invention possess valuable centr
