102771-66-4

Basic information

• Product Name: 5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID;5-(TrifluoroMethoxy)picolinic acid;2-Pyridinecarboxylic acid, 5-(trifluoromethoxy)-
• CAS NO: 102771-66-4
• Molecular Formula: C7H4F3NO3
• Molecular Weight: 207.11
• Mol File: 102771-66-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 123-125 °C(Solv: ethyl acetate (141-78-6); cyclohexane (110-82-7))
• Boiling Point: 257.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.527±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.29±0.10(Predicted)
• CAS DataBase Reference: 5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID(102771-66-4)
• EPA Substance Registry System: 5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID(102771-66-4)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 102771-66-4(Hazardous Substances Data)

Usage

Description

5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID is an organic compound characterized by its unique molecular structure, which features a trifluoromethyl group attached to a pyridine ring and a carboxylic acid functional group. 5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID is known for its potential applications in various industries, particularly in the pharmaceutical sector, due to its chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID is used as a reactant for the preparation of carboxamides, which serve as modulators of the integrated stress pathway. These carboxamides are essential in the development of therapeutic agents targeting various diseases and conditions, including those related to cellular stress response and protein homeostasis.
In the synthesis of carboxamides, 5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID plays a crucial role as a building block, providing the necessary functional groups for further chemical modifications and the formation of biologically active molecules. The trifluoromethyl group and the pyridine ring contribute to the overall stability and lipophilicity of the resulting carboxamides, potentially enhancing their pharmacokinetic properties and cellular uptake.
Furthermore, the carboxylic acid functionality of 5-(TRIFLUOROMETHOXY)PYRIDINE-2-CARBOXYLIC ACID allows for the formation of amides with various amines, leading to a diverse range of carboxamide derivatives with different biological activities. This versatility makes it a valuable compound in the design and synthesis of novel therapeutic agents targeting the integrated stress pathway and other related cellular processes.