1027787-52-5

Upstream product

• 93296-09-4 4-methoxyphenylzinc chloride 
• 317802-33-8 3-iodo-5-methoxy-1-[(4-methylphenyl)sulphonyl]-1H-indole 
• 139717-71-8 5-methoxy-N-(4-toluenesulfonyl)-1H-indole 

Downstream Products

• 81344-98-1 5-methoxy-3-(4-methoxyphenyl)-1H-indole 

Relevant academic research and scientific papers

Silver-Mediated Intramolecular Friedel-Crafts-Type Cyclizations of 2-Benzyloxy-3-bromoindolines: Synthesis of Isochromeno[3,4-b[ indolines and 3-Arylindoles

We disclose a silver-mediated intramolecular Friedel-Crafts-type cyclization of 2-benzyloxy-3-bromoindolines to afford an untapped family of isochromeno[3,4-b[indolines and 3-arylindoles, in which deformylative arylation of 2-(4-methoxybenzyloxy)-3-bromoindolines is reported for the first time. The isochromeno[3,4-b[indolines can be readily transformed into other heterocyclic moieties.

COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS

The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, Aβ protein or α-synuclein protein aggregation.