10278-40-7

Basic information

• Product Name: 3,4-dichloro-N-(4-nitrophenyl)benzamide
• Synonyms: benzamide, 3,4-dichloro-N-(4-nitrophenyl)-
• CAS NO: 10278-40-7
• Molecular Formula: C₁₃H₈Cl₂N₂O₃
• Molecular Weight: 311.1202
• Mol File: 10278-40-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 406.4°C at 760 mmHg
• Flash Point: 199.6°C
• Density: 1.524g/cm³
• Vapor Pressure: 8.13E-07mmHg at 25°C
• Refractive Index: 1.68
• CAS DataBase Reference: 3,4-dichloro-N-(4-nitrophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dichloro-N-(4-nitrophenyl)benzamide(10278-40-7)
• EPA Substance Registry System: 3,4-dichloro-N-(4-nitrophenyl)benzamide(10278-40-7)

Safety Data

• Hazardous Substances Data: 10278-40-7(Hazardous Substances Data)

Upstream product

• 51-44-5 3,4-dichlorbenzoic acid 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 926273-98-5 N-(4-aminophenyl)-3,4-dichlorobenzamide 

Relevant articles and documents

Discovery of novel VEGFR-2 inhibitors embedding 6,7-dimethoxyquinazoline and diarylamide fragments

VEGF/VEGFR-2 signaling plays a critical part in tumor angiogenesis. Inhibition of this pathway has been considered as a promising approach for cancer treatment. In this work, a series of 6,7-dimethoxy-4-anilinoquinazoline derivatives bearing diarylamide moiety were designed, synthesized and evaluated as potent inhibitors of VEGFR-2 kinase. Their in vitro antiproliferation activities against two human cancer cell lines Hep-G2 and MCF-7 have also been determined. Among them, compound 14b exhibited the most potent inhibitory activity against VEGFR-2 with IC50 value of 0.016 ± 0.002 μM and it showed the most potent antiproliferative effect against Hep-G2 and MCF-7 with IC50 values at low-micromolar range. Molecular docking studies revealed that these compounds represented by the most potent compound 14b could bind well to the ATP-binding site of VEGFR-2, which suggested that compound 14b could be a potential anticancer agent targeting VEGFR-2.